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KMID : 0613820160260101196
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Journal of Life Science
2016 Volume.26 No. 10 p.1196 ~ p.1201
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Isolation and Identification of Secondary Metabolites from the Ovary of Nelumbo nucifera
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Ji Seung-Heon
Lee Jeong-Hoon
Lee Seung-Eun
Lee Young-Seob
Kim Geum-Soog
Ahn Young-Sup
Baik Nam-In
Lee Yi
Lim Heung-Bin
Lee Dae-Young
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Abstract
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The ovary parts of Nelumbo nucifera were extracted in 80% methanol (MeOH), and the concentrated extract was then partitioned using n-hexane, ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O, successively. Using an octadecyl silica gel (ODS) column, silica gel (SiO2) column chromatography, and a HPLC purification system, five compounds were isolated from the n-hexane fraction obtained from the extract of N. nucifera ovary. The chemical structures of the metabolites were determined using several spectroscopic methods, including NMR and GC/MS and MS of 1-eicosanol (1), cycloartenol (2), trans-squalene (3), pentadecanoic acid (4), and β-sitosterol (5). This study is a first attempt to isolate and identify secondary metabolites from the ovary of N. nucifera. The results indicated that the extract of N. nucifera ovary has biological effects, such as antibacterial and -tumor activity. Therefore, it could decrease the risk of HIV transmission through breastfeeding.
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KEYWORD
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Column chromatography, GC/MS, Nelumbo nucifera, NMR
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